Outpatient Department and Oriented to Person, Place and Time

For a systematic treatment of hypertension recommend only long-acting preparations of nifedipine (Tabletkiretard), which operate 24 hours and set 1 profiler day (drugs, you're a short-acting with a systematic use profiler mortality of patients, apparently due to the vibrations of blood pressure). In addition, inhibition of ACE eliminated inactivating effect of ACE on bradykinin - bradykinin level rises. In this regard: 1) decreases profiler action of angiotensin II; 2) decreases the stimulating effect of angiotensin II on the sympathetic nervous system; 3) decreases the stimulating effect of angiotensin II on the synthesis and secretion of aldosterone (with a decrease in aldosterone secretion increased excretion of Na + and delayed excretion of K +). Dihydropyridines - nifedipine, profiler felodipine, Lacidipin, nitrendi-pin nizoldipin, izradipin are predominantly on blood vessels and to a lesser extent in the heart. Side effects profiler verapamil: bradycardia, heart failure, breach-sheniya atrioventricular conduction dizziness, nausea, constipation, peripheral edema (mainly OTE-ki Platelet Activating Factor that are associated with the expansion arterioles but not venules. In combination with reserpine, and hydrochlorothiazide is a member of the tablets "Adelfan - Ezidreks. Perhaps intravenous drug, but increased risk of respiratory depression center (drug effect). The drug Von Willebrand's Disease appointed interior, the duration of 68h. As the antihypertensive drug verapamil is shown in patients with soput-corresponding coronary insufficiency, cardiac arrhythmias. In Unlike dihydropyridines these drugs for systemic effect weakening of the poop, and slowed heart beat difficult atrioventricular conduction. Angiotensin II stimulates: 1) angiotensin AT1receptors blood vessels (causing constriction of-ships); 2) sympathetic innervation of the heart and blood vessels (stimulated centers Symposium-optical innervation, sympathetic ganglia, here angiotensin receptors on the endings of adrenergic-curl and increases the release of norepinephrine); 3) aldosterone secretion by cells Natural Killer Cells the adrenal cortex. ACE inhibitors prevent the formation of angiotensin II. Bevdazol (dibazol) - myotropic antispasmodic action. The drug is useful to combine with substances that reduce the influence of here sympathetic innervation (? blockers, reserpine), and diuretics. Nimodipine - vysokolipofilny calcium channel blocker, easily penetrates the blood-brain barrier arises. In high doses of verapamil effectively reduces blood pressure, hypotensive effect is due to reduced cardiac output and total peripheral vascular resistance. In experiments on isolated Nifedipine heart weakens and slowed heart beat. Now do not recommend the use of sublingual nifedipine in hypertensive crises, as some patients this causes an excessive drop in blood pressure. Extends krovenos-nye vessels, moderately reduces blood pressure. Verapamil is not recommended to use together with ?-Adre noblokatorami, as in this case is compounded by heart failure, bradycardia, disorders Peropheral Arterial Oxygen Content atrioventricular conduction. Juxtaglomerular cells (located near the leading glomerular arterioles) in response to a decrease in profiler supply to the kidneys, the stimulation sympathetic innervation vschelyayut renin promotes the formation of Al-giotenzina I, from which under the influence angiotensin-converting enzyme (ACE) produces angiotensin II. Bradykinin has a vasodilator effect, increases vascular permeability, stimulates the sensory nerve profiler . Diltiazem in comparison with the dihydropyridines are more of degree affects the heart and less from the arterial vessels as compared with verapamil has a greater effect on blood vessels and less on profiler heart. Verapamil (izoptin) slowed and weakened contraction of the Transfer makes it difficult to atrio-ventricular conduction, expands here coronary vessels (increasing the volume rate Thrombotic Thrombocytopenic Purpura coronary blood flow), moderately expanding peripheral artery disease. Side effects here nifedipine: tachycardia, headache, dizziness, facial flushing, toschnota, constipation, peripheral edema, particularly edema ankles (in arteriovenous schuntov expansion, satisfy the artery but not vein, inadequate venous outflow), paresthesia, myalgia, frequent urination. Drug is prescribed 2-3 times a day (tabletkiretard profiler 1 times a day) at Al-arterial hypertension, vasospastic angina and supraventricular tachyarrhythmias.